Design and Stability Improvement of Pectin-Based Red Blood Cell-Mimicking Microcapsules for Oxygen Therapeutics-Reference-Cited by-同舟云学术

Design and Stability Improvement of Pectin-Based Red Blood Cell-Mimicking Microcapsules for Oxygen Therapeutics

Published:2021-09-01 Issue:9 Volume:17 Page:1798-1805
ISSN:1550-7033
Container-title:Journal of Biomedical Nanotechnology
language:en
Short-container-title:j biomed nanotechnol

Author:

Phakousonh Damien¹,Wang Yale²,Schlicht Sabrina¹,Wiskirchen Sam¹,Bos Trevor¹,Ren Lixia³,Chen Junhong²,Hua Xiaolin⁴,Lee Jung¹,Krishnan Sasirekha⁵,Suresh K. Shoma⁵,Jaisankar Abinaya⁵,Ramalingam Murugan⁵,Zhang Wujie¹

Affiliation:

1. BioMolecular Engineering Program, Physics and Chemistry Department, Milwaukee School of Engineering, Milwaukee, WI 53202, USA

2. Mechanical Engineering Department, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA

3. School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China

4. Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China

5. Biomaterials and Organ Engineering Group, Centre for Biomaterials, Cellular and Molecular Theranostics, School of Mechanical Engineering, Vellore Institute of Technology, Vellore 632014, TamilNadu, India

Abstract

A pectin-oligochitosan microcapsule system has recently been developed for novel oxygen therapeutic design. To improve the stability of the pectin-oligochitosan microcapsules in physiological conditions, both covalent (glutaraldehyde) and noncovalent (Mn2+ and Ca2+) cross-linkers were tested. The chemistry and morphology of the microcapsules were studied using FTIR and SEM, respectively. Results showed that glutaraldehyde is an effective cross-linker, even at low concentrations and short incubation times, and the glutaraldehyde cross-linking does not negatively impact the morphology of the microcapsules. Moreover, it was confirmed that the hemoglobin could be retained within the microcapsules with a minimal release.

Publisher

American Scientific Publishers

Subject

Pharmaceutical Science,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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