Application value of a nano-siRNA delivery system in treatment against senile cataracts by modulating apoptosis in lens epithelial cells-Reference-Cited by-同舟云学术

Application value of a nano-siRNA delivery system in treatment against senile cataracts by modulating apoptosis in lens epithelial cells

Published:2024-06-01 Issue:6 Volume:14 Page:942-945
ISSN:2158-5849
Container-title:Materials Express
language:en
Short-container-title:mat express

Author:

Wei Xiaoqing¹,Wang Xiaoxing²,Wang Ping¹

Affiliation:

1. Affiliated Renhe Hospital of China Three Gorges University Institute of Ophthalmology, China Three Gorges University, Yichang, 443001, China

2. Research Center of Basic and Clinical Pathology, China Three Gorges University, Yichang, 443002, China

Abstract

In this study, a novel nano-siRNA delivery system loaded with anti-ESR1 siRNA was designed. In a biological study, the new system was evaluated for the treatment and care of senile cataracts. The system significantly upregulated the expression level of the anti-apoptotic protein BCL-2, while significantly inhibiting the expression level of the inhibitory apoptotic protein BAX, thereby regulating apoptosis in lens epithelial cells. The system can be developed as a drug for the treatment of senile cataracts.

Publisher

American Scientific Publishers

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