Biological properties of multifocal intraocular lens and evaluation of their visual quality in cataract

Abstract

To enhance the visual quality of cataract patients after surgery, we conducted an innovative investigation into the biological properties of multifocal intraocular lens (MIOL) for cataract treatment. Our studies revealed that hydrophilic acrylates exhibited optimal biocompatibility with lens epithelial cells, effectively enhancing cell activity and inhibiting epithelial-mesenchymal transition. Moreover, hydrophilic acrylates demonstrated superior inhibition against Staphylococcus epidermidis attachment, thereby reducing the risk of postoperative infection. In terms of postoperative visual quality assessment, MIOL exhibited superior efficacy in enhancing patients’ visual acuity levels, particularly for corrected near and intermediate distances. Additionally, MIOL exhibits enhanced visual acuity within the defocus curve range of −1.00 D to −4.00 D. Compared to the single-focal IOL group, patients in the MIOL group exhibited enhanced contrast sensitivity across all spatial frequencies. Therefore, hydrophilic acrylate MIOL displayed excellent biocompatibility and resistance against bacterial adhesion while significantly improving patients’ visual quality at near and intermediate distances as well as contrast sensitivity.