Therapeutic effect of saikosaponin-d on airway allergy in asthma

Abstract

Saikosaponin-d (SSd) is a compound extracted from Bupleurum chinense, a traditional ethnic medicine known for its antipyretic and analgesic properties. In this study, our research group established a mouse allergic asthma model with ovalbumin (OVA) as the inducer, and evaluated the therapeutic effects of different SSd groups. We measured lgE levels, cytokine levels, and the number of innate lymphocytes 2 (ILC2) to assess the effect of SSd on allergic asthma, and detected miR-155 expression. The results show that SSd reduces the levels of inflammatory factor in asthmatic mouse models, alleviating airway inflammation by inhibiting the regulation of lung ILC2. At the same time, it can reduce the downstream inflammatory level factors. In addition, SSd reduced the expression of miR-155 in the lung. These results suggest that SSd plays an important role in the treatment of airway inflammation, and its mechanism may be related to the regulation of miR-155.