Evaluation of the clinical efficacy of the composition based on superoxide dismutase and cluster silver in combination with an energy protector in therapy chronic generalized periodontitis

Abstract

The paper presents the results of studies on the effect of a drug composition in the form of gel, which includes two main components: a key enzyme of antioxidant defense of the body — superoxide dismutase (SOD) and a broad-spectrum antibacterial component in relation to aerobic, anaerobic, gram-positive and gram-negative microflora, including antibiotic-resistant — cluster silver and a metabolic drug on the therapeutic efficacy of the use of these drugs in the complex pharmacotherapy of patients with chronic generalized periodontitis (CHGP) moderate to severe severity. Based on the data of clinical symptoms (pain, hyperemia, pathological mobility, etc.), indicators of the index assessment of the state of periodontal status (PI, PMA), the mathematized Schiller-Pisarev test and the index of interdental papillae bleeding (SBI) according to Muhlemann-Cowell observed the dynamics of changes in the state of the oral cavity and periodontal tissues in patients with CHGР. It was established that the pharmacotherapy with the additional inclusion in the complex of drugs of traditional drug therapy of a gel, including SOD and cluster silver, as well as a drug of metabolic action, contributed to a more rapid relief of acute inflammatory processes in periodontal tissues, a decrease in the severity of destructive changes, a decrease in the manifestation of pathological symptoms, improving the reparative regeneration of periodontal support tissues and increasing the effectiveness of treatment of patients with CHGP.