Medication-related osteonecrosis of the jaws associated with the use of bone-modifying agents: new studies

Abstract

The relevance of the study is associated with the widespread use of osteomodifying agents in patients with bone metastases and osteoporosis. A serious complication associated with the use of bisphosphonates and other osteomodifying agents is known — medical osteonecrosis of the jaws, but the pathogenesis of this disease has not been fully studied. With drug-induced osteonecrosis of the jaws in oncological patients with bone metastases, therapy with osteomodifying agents is suspended, which can cause a decrease in the patient's life span. This is due to the importance of prevention, early diagnosis, and rapid treatment of patients with drug-induced osteonecosis. The aim of the work was to analyze the studies carried out in 2021—2023 on new methods of diagnosis, treatment, prevention of medical osteonecrosis of the jaws. The literature review is based on the analysis of published studies according to the PubMed electronic resource. The analysis of the literature data showed that bisphosphonates and other osteomodifying agents are widely used in oncology and the profile of age-related changes in the human bone system. The use, therapeutic effects and complications of therapy with osteomonefying agents are being investigated all over the world. Cone-beam computed tomography remains the "gold standard" in the diagnosis of medicamental osteonecrosis of people. Antibiotic therapy is considered as an effective method of treatment. It is proposed to use hyperbaric oxygenation, laser treatment, bone resection under fluorescence control, photodynamic therapy, introduction of a biomaterial based on tricalcium phosphate, administration of teriparatide and atorvastatin as additional treatment methods. Regular dental examinations are the most effective means of preventing drug-induced osteonecrosis. The study of pathogenesis, new methods of therapy and prevention of drug-induced osteonecrosis of the jaws remains urgent.