Association of normal oral mucosa with DNA of the main types of oncogenic viruses-Reference-Cited by-同舟云学术

Association of normal oral mucosa with DNA of the main types of oncogenic viruses

Published:2020-06 Issue:2020 2 (91) Volume: Page:60-63
ISSN:2408-9753
Container-title:Stomatology for All / International Dental review
language:ru
Short-container-title:IDR

Author:

Kutukova S.I.¹,Chukhlovin A.B.¹,Yaremenko A.I.¹,Ivaskova Yu.V.¹,Razumova A.Ya.¹,Ermakova T.S.²

Affiliation:

1. Pavlov First Saint Petersburg State Medical University

2. City Clinical Oncology Center, Saint-Petersburg

Abstract

The aim of the study was to assess the prevalence of DNA viruses (HSV I and II, CMV, EBV, HPV6.11, HPV16 and HPV18) in the native oral mucosa of healthy volunteers (n=50; 30 men (60.0%), 20 women (40.0%); 25—74 years, median age — 55.0 years (95% CI 47.60-56.76)). All samples of the normal oral mucosa were detected by real-time PCR to detect viral DNA. The majority of the examined — 76% (33/50) — revealed the DNA: one type of viral DNA in 17 (38.00%) of the examined, a combination of the two types in 14 (28.00%). In the normal oral mucosa, DNA of Epstein-Barr virus was significantly more often detected: 15 (30.00%) (p = 0.0276) and human papilloma viruses 27 (54.00%) (p <0.0001), especially HPV-18 (24 (48.00%)): mono-association in 9 (18.00%) examined and in 7 (14.00%) in combination with EBV DNA (p = 0.0253).

Publisher

Stomatology for All - International Dental Review

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