Abstract
A challenge in conducting pediatric research is selecting reliable, valid measurement protocols, across a range of domains, that are appropriate for the developmental level of the study population. The purpose of this report is to introduce the research community to the Pediatric Development Research Domain of the National Institutes of Health (NIH)–supported PhenX Toolkit (consensus measures for Phenotypes and eXposures). The PhenX Toolkit provides a catalog of recommended measurement protocols to address a wide range of research topics that are suitable for inclusion in a variety of study designs. In 2018, the Pediatric Development Working Group of experts identified 18 well-established protocols of pediatric development for inclusion in the Toolkit to complement existing protocols. Collectively, the protocols assess parenting, child care attendance and quality, peer relationships, home environment, neonatal abstinence, emotional and behavioral functioning, and other factors that influence child development. The Toolkit provides detailed data collection protocols, data dictionaries, and worksheets to help investigators incorporate these protocols into their study designs. Using standard protocols in studies with pediatric participants will support consistent data collection, improve data quality, and facilitate cross-study analyses to ultimately improve child health.
Reference56 articles.
1. 1. Tarazi C, Skeer M, Fiscella K, Dean S, Dammann O. Everything is connected: social determinants of pediatric health and disease. Pediatr Res. 2016;79(1-2):125-6. 10.1038/pr.2015.22026841091
2. 2. Gitterman DP, Langford WS, Hay WW Jr. The uncertain fate of the National Institutes of Health (NIH) pediatric research portfolio. Pediatr Res. 2018;84(3):328-32. 10.1038/s41390-018-0035-729976967
3. 3. National Institutes of Health. Inclusion of children in clinical research: change in NIH definition. NOT-OD-16-010. 2015. https://grants.nih.gov/grants/guide/notice-files/not-od-16-010.html
4. 4. Maiese DR, Hendershot TP, Strader LC, Wagener DK, Hammond JA, Huggins W. PhenX-establishing a consensus process to select common measures for collaborative research. RTI Press Publication MR-0027-1310. 2013. 10.3768/rtipress.2013.mr.0027.1310
5. 5. National Institutes of Health. High-priority phenotype and exposure measures for cross-study analysis in genome-wide association studies (U01). RFA-HG-07-006. 2007. https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-07-006.html