Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients

Author:

Di Paolo A.,Danesi R.,Falcone A.,Cionini L.,Vannozzi F.,Masi G.,Allegrini G.,Mini E.,Bocci G.,Conte P.F.,Del Tacca M.

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference18 articles.

1. Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropynmidine dehydrogenase deficiency;Takimoto;Clin Cancer Res,1996

2. Life-threatening toxicity in a dihydropynmidine dehydrogenase-deficient patient after treatment with topical 5-fluorouracil;Johnson;Clin Cancer Res,1999

3. Dihydropynmidine dehydrogenase activity Prognostic partner of 5-fluorouracil?;Allegra;Clin Cancer Res,1999

4. Distribution and inhibition of dihydrouracil dehydrogenase activities in human tissues using 5-fluorouracil as a substrate;Ho;Anticancer Res,1986

5. Dihydropynmidine dehydrogenase activity in human peripheral blood mononuclear cells and liver Population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy;Lu;Cancer Res,1993

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