Immunohistochemical determination of p53 protein does not predict clinical response in advanced colorectal cancer with low thymidylate synthase expression receiving a bolus 5-fluorouracil—leucovorin combination

Author:

Cascinu S.,Catalano V.,Aschele C.,Barni S.,Debernardis D.,Gallo L.,Bandelloni R.,Staccioli M.P.,Baldelli A.M.,Brenna A.,Valenti A.,Muretto P.,Catalano G.

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference16 articles.

1. Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells;Berger;Mol Pharmacol,1985

2. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fiuorouracil in human colorectal and gastric tumors;Johnston;Cancer Res,1995

3. A. Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy;Aschele;J Clin Oncol,1999

4. Thymidylate synthase protein expression in advanced colon cancer: Correlation with the site of metastasis and the clinical response to leucovorin-modulated bolus 5-fluorouracil;Cascinu;Clin Cancer Res,1999

5. Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin;Leichman;J Clin Oncol,1997

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