Artificial Cornea: Towards a Synthetic Onlay for Correction of Refractive Error

Author:

Xie Ruo Zhong1,Stretton Serina1,Sweeney Deborah F.1

Affiliation:

1. The Cooperative Research Centre for Eye Research and Technology (CRCERT), The University of New South Wales, Sydney, Australia

Abstract

Synthetic onlays that are implanted onto the surface of the cornea have the potential to become an alternative to spectacles and contact lenses for the correction of refractive error. A successful corneal onlay is dependent on development of a biocompatible polymer material that will maintain a healthy cornea after implantation and that will promote growth of corneal epithelial cells over the onlay, and development of a method for attachment of the onlay with minimal surgical invasiveness. The ideal onlay should be made of a material that is highly permeable yet has sufficient surface characteristics to stimulate stable and firm attachment of the corneal epithelium over the onlay. Recent research indicates that collagen I coated polymer materials that mimic the basement membrane of the corneal epithelium promote the most favorable growth of epithelial cells in vivo in comparison to wholly biological or synthetic materials.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

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1. Artificial Corneal Transplantation and the Safe Recovery of Vision in the COVID-19 Pandemic;Bioengineering and Biomedical Signal and Image Processing;2021

2. Developments in the correction of presbyopia II: surgical approaches;Ophthalmic and Physiological Optics;2014-04-10

3. Biomaterials for refractive correction: corneal onlays and inlays;Science China Chemistry;2014-03-01

4. Synthetic corneal implants;Biomaterials and Regenerative Medicine in Ophthalmology;2010

5. Glucose-Permeable Interpenetrating Polymer Network Hydrogels for Corneal Implant Applications: A Pilot Study;Current Eye Research;2008-01

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