Methods for the determination of M class anti-T. pallidum antibodies for early diagnostics of syphilis

Abstract

The review covers issues related to the present-day administration of laboratory blood test methods for the determination of specific Class M immunoglobulins against antigens of the syphilis pathogen, T. pallidum (immune-enzyme assay, immunofluorescence reaction, linear immunoblotting). Indications and diagnostic features of the aforesaid medical methods for early diagnostics of acquired or congenital syphilis were determined; cases of reinfection were verified and the intensity of the infection was assessed in the patients who had previously received specific treatment. The article provides recommendations for using specific IgM determination methods described in present-day Russian and foreign guides and standards of syphilis diagnostics.