Proteome technologies in studying the pathogenesisof psoriasis

Abstract

Psoriasis is one of the most prevalent inflammatory dermatoses. At the same time, its pathogenesis has not been studied in full. Proteome profiling is currently a promising method to study the biological mechanisms of developing different diseases. Proteome technologies make it possible to detect changes in the skin protein profile in psoriatic patients and identify the revealed proteins. The proteins serve as potential targets for drugs or biomarkers for assessing the patients individual drug response. The article describes the key achievements in the field of studying the pathogenesis of psoriasis using proteome technologies (two-dimensional electrophoresis and mass spectrometry) set out in the latest literature sources, and also analyzes the results of the authors studies aimed at detecting proteins being markers of the patients response to the infliximab therapy.