Abstract
Psoriasis is an immune-mediated disease with a complex pathogenesis. The close relationship between the development of psoriasis and the adaptive immune response is already known. However, recent data have shown that innate immune cells also play an important role in the development of psoriasis. Congenital lymphoid cells, dendritic cells, T cells, NK cells, and NKT lymphocytes are activated in psoriasis, contributing to disease pathology through IL-17-dependent and independent mechanisms. During disease progression, T cells secrete proinflammatory cytokines that induce and exacerbate the course of psoriasis. T cells have memory cell properties that respond rapidly to secondary stimulation, which contributes to disease relapse. This article presents an overview of recent findings demonstrating the role of innate immunity in psoriasis.
Publisher
Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov
Subject
Infectious Diseases,Dermatology
Cited by
1 articles.
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1. Multimorbid pathology at psoriasis (scientific review);HERALD of North-Western State Medical University named after I.I. Mechnikov;2024-07-03