Darier–White’s follicular dyskeratosis. Experience of successful therapy

Abstract

Darier–White’s follicular dyskeratosis is an autosomal dominant hereditary dermatosis, which is based on pathological keratinization due to impaired adhesion between keratinocytes, manifested mainly in the form of hyperkeratotic follicular papules on seborrheic areas of the skin. Therapy of rare genodermatosis still presents difficulties in the tactics of choosing a treatment method for each individual patient. Currently, there are no regulated methods of treating this disease. Isotretinoin is a well-studied drug, the profile points of application of which are moderate and severe forms of acne, rosacea, but recently indications for the use of isotretinoin have been increasing. In this article presents a clinical case of Darier–White’s follicular dyskeratosis and demonstrates the successful experience of therapy of rare genodermatosis with isotretinoin.