Mechanisms of the formation of Neisseria gonorrhoeae resistance to cephalosporins-Reference-Cited by-同舟云学术

Mechanisms of the formation of Neisseria gonorrhoeae resistance to cephalosporins

Published:2012-10-15 Issue:5 Volume:88 Page:44-51
ISSN:2313-6294
Container-title:Vestnik dermatologii i venerologii
language:
Short-container-title:Vestnik dermatologii i venerologii

Author:

KOZHUSHNAYA O S,VASILIYEVA YE L,FRIGO N V,SOLOMKA V S

Abstract

The authors provide a review of the present-day literature data on the issues of studying the mechanisms of the formation of Neisseria gonorrhoeae resistance to third-generation cephalosporins. Studies in this field are needed in connection with the occurrence of strains resistant to third-generation cephalosporins as well as low-sensitivity strains. The authors emphasize the importance of mutations in porB, penA, mtrR, penB and ponA genes in the development of Neisseria gonorrhoeae resistance to β-lactam antibiotics and describe the prospects of studying the mosaic structure of the penA gene encoding the РВР2 protein as well as spatial structure of this protein.

Publisher

Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov

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