Affiliation:
1. National Research Center for Hematology
2. State Scientific Center of Dermatovenereology and Cosmetology
Abstract
The aimof the study is to present a successful case in treating primary cutaneous anaplastic large cell lymphoma (PCALCL) occurring with common lesions of the skin and lung tissue.Materials and methods. For the verification of the diagnosis in a patient with three types of skin elements (spot, thin plaque with and without ulceration), differential diagnosis was performed between ulcerative pyoderma gangrenosum, PCALCL, large-cell transformation of mycosis fungoides, and secondary skin lesions under the nodal ALK-negtaive ALCL. A complex of studies, including histological, immunohisto - chemical, cytogenetic studies of skin tumor biopsy, allowed the verification of the PCALCL diagnosis. For the treatment of the patient, intensive induction chemotherapy was used followed by high-dose consolidation and autologous transplantation of hematopoietic stem cells.Results. The selected treatment tactics allowed a long-term complete remission of the disease to be achieved in a patient from the poor prognosis group.Conclusion. An algorithm for the differential diagnosis and tactics of treating is presented for a patient with primary anaplastic large cell lymphoma with a widespread skin lesion and extradermal foci.
Publisher
Rossijskoe Obschestvo Dermatovenerologov i Kosmetologov
Reference32 articles.
1. Vose J., Armitage J., Weisenburger D. International peripheral T-cell and natural killer / T-cell lymphoma study: pathology findings and clinical outcomes. International T-Cell Lymphoma Project. J Clin Oncol. 2008 Sep 1;26(25):4124–4130. DOI: 10.1200/JCO.2008.16.4558
2. Swerdlow S. H., Campo E., Harris N. L., Jaffe E. S., Pileri S. A., Stein H., Thiele J., Arber D. A., Hasserjian R. P., Le Beau M. M., Orazi A., Siebert R. WHO classification of tumors of haematopoietic and lymphoid tissues. Lyon: IARC, 2017:395–396.
3. Kadin M. E., Carpenter C. Systemic and primary cutaneous anaplastic large cell lymphomas. Semin Hematol. 2003;40(3):244–256.
4. Bekkenk M. W., Geelen F. A., van Voorst Vader P. C., Heule F., Geerts M. L., van Vloten W. A., Meijer C. J., Willemze R. Primary and secondary cutaneous CD30(+) lymphoproliferative disorders: a report from the Dutch Cutaneous Lymphoma Group on the long-term follow-up data of 219 patients and guidelines for diagnosis and treatment. Blood. 2000;95(12):3653–3661.
5. Stein H., Foss H. D., Dürkop H., Marafioti T., Delsol G., Pulford K., Pileri S., Falini B. CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood. 2000;96(12):3681–3695.