Blood periostin/procalcitonin index in patients with asthma and asthma-COPD overlap-Reference-Cited by-同舟云学术

Blood periostin/procalcitonin index in patients with asthma and asthma-COPD overlap

Published:2023-09-06 Issue:5 Volume:33 Page:657-662
ISSN:2541-9617
Container-title:PULMONOLOGIYA
language:
Short-container-title:Pulʹmonologiâ (Mosk.)

Author:

Trofimov V. I.¹^ORCID,Baranov D. Z.¹^ORCID,Mineev V. N.¹^ORCID

Affiliation:

1. Federal State Budgetary Educational Institution of Higher Education “Academician I.P.Pavlov First St. Petersburg State Medical University” of the Ministry of Healthcare of Russian Federation

Abstract

The significant prevalence of asthma and asthma-COPD overlap (ACO) necessitates further rationalization of diagnostic and treatment approaches and emphasizes importance of studying the pathogenesis of bronchial obstructive diseases. Well-known markers of allergic and infectious inflammation such as periostin and procalcitonin, respectively, have shown their utility in pulmonology. The aim of this study is to analyze the diagnostic value of blood periostin/procalcitonin index as a complex parameter reflecting both allergic and non-allergic inflammation. Methods. First, we calculated blood periostin/procalcitonin index. Then we compared this index between two groups using the Mann – Whitney test. Results. Patients with non-allergic asthma had lower blood periostin/procalcitonin index compared to the patients with allergic asthma (p = 0.003). Blood periostin/procalcitonin index correlated well with diagnosis in patients with asthma and ACO in our clinical cases. Conclusion. Blood periostin/ rocalcitonin index has demonstrated its clinical utility as a complex inflammatory parameter. Its high values indicate active allergic inflammation. This index can be used to correct glucocorticoid and antibacterial treatment.

Publisher

Scientific and Practical Reviewed Journal Pulmonology

Subject

Pulmonary and Respiratory Medicine

Reference16 articles.

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