Significance of N-acetylcysteine in clinical practice-Reference-Cited by-同舟云学术

Significance of N-acetylcysteine in clinical practice

Published:2023-09-05 Issue:5 Volume:33 Page:679-688
ISSN:2541-9617
Container-title:PULMONOLOGIYA
language:
Short-container-title:Pulʹmonologiâ (Mosk.)

Author:

Leshchenko I. V.¹^ORCID,Esaulova N. A.²^ORCID

Affiliation:

1. Federal State Budgetary Educational Institution of Higher Education “Ural Federal State Medical University”, Healthcare Ministry of Russia; Ural Federal Research Institute of Phthisiology and Pulmonology – a Branch of National Medical Research Center for Phthisiology, Pulmonology and Infectious Diseases, Healthcare Ministry of Russia; Limited Liability Company “Novaya bol’nitsa” Clinical Association

2. Federal State Budgetary Educational Institution of Higher Education “Ural Federal State Medical University”, Healthcare Ministry of Russia; Ural Federal Research Institute of Phthisiology and Pulmonology – a Branch of National Medical Research Center for Phthisiology, Pulmonology and Infectious Diseases, Healthcare Ministry of Russia

Abstract

N-acetylcysteine (NAC) is a mucolytic and antioxidant with a variety of properties. The clinical use of NAC spans more than 35 years, during which the emphasis has been on a multifaceted action and broad spectrum of therapeutic indications. Information is available on the efficacy of NAC in the prevention of contrast-induced nephropathy, studies on the role of NAC in the treatment of pulmonary and coronary disease, etc. The purpose of this review is to analyze the efficacy and safety of NAC in respiratory clinical practice. Conclusion. NAC is a drug with a unique variety of properties and treatment options. The drug has proven its efficacy and safety in real pulmonology practice.

Publisher

Scientific and Practical Reviewed Journal Pulmonology

Subject

Pulmonary and Respiratory Medicine

Reference36 articles.

1. Webb W.R. Clinical evaluation of a new mucolytic agent acetylcysteine. J. Thorac. Cardiovasc. Surg. 1962; 44 (3): 330–343. DOI: 10.1016/S0022-5223(19)32956-3.

2. Reas H.W. The effect of N-acetylcysteine on the viscosity of tracheobronchial secretion in cystic fibrosis of the pancreas. J. Pediatr. 1963; 62: 31–35. DOI: 10.1016/s0022-3476(63)80067-0.

3. De Vries N., De Flora S. N-acetyl-l-cysteine. J. Cell Biochem. 1993; 17F: 270–278. DOI: 10.1002/jcb.240531040.

4. De Flora S., Izzotti A., D'Agostini F., Cesarone C.F. Antioxidant activity and other mechanisms of thiols involved in chemoprevention of mutation and cancer. Am. J. Med. 1991; 91 (3, Suppl. 3): 122–130S. DOI: 10.1016/0002-9343(91)90295-9.

5. De Flora S., Cesarone C.F., Balansy R.M. et al. Chemopreventive properties and mechanisms of N-acetylcysteine. The experimental background. J. Cell Biochem. Suppl. 1995; 22: 33–41. DOI: 10.1002/jcb.240590806.