Posthypercapnic syndrome

Author:

Nguyen H. C.1ORCID,Baranova I. A.1ORCID,Chuchalin A. G.1ORCID

Affiliation:

1. Federal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian Federation

Abstract

Hypercapnic respiratory failure is a common cause of hospitalization and death in patients with chronic obstructive pulmonary disease (COPD).The aim of this work was to analyze the pathophysiological mechanisms and clinical picture of hypercapnic respiratory failure and to discuss the tactics of managing a patient with COPD and posthypercapnic alkalosis that developed during treatment using a clinical case as an example.Conclusion. To date, the search for new treatments for posthypercapnic alkalosis is still relevant, but there are few published studies on this topic. Acute problems in mixed metabolic disorders can be solved with an integrated therapeutic approach that includes the use of medical gases.

Publisher

Scientific and Practical Reviewed Journal Pulmonology

Subject

Pulmonary and Respiratory Medicine

Reference20 articles.

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2. Avdeev S.N. [Intensive care in pulmonology]. Moscow: Atmosfera; 2014 (in Russian).

3. Feller-Kopman D.J., Schwartzstein R.M. Mechanisms, causes, and effects of hypercapnia. UpToDate. 2022. Available at: https://www.uptodate.com/contents/mechanisms-causes-and-effects-of-hypercapnia/print [Accessed: October 10, 2022].

4. Grippi M.A., Tino G. Pulmonary function testing. In: Grippi M.A., Elias J.A., Fishman J.A. et al., eds. Fishman's Pulmonary Diseases and Disorders. 5nd Edn. New York: McGraw-Hill Education; 2015. Available at: https://accessmedicine.mhmedical.com/content.aspx?bookid=1344§ionid=81187235

5. Аvdeev S.N. [Pathologic physiology of exacerbations of chronic obstructive pulmonary disease]. Vestnik anesteziologii i reanimatologii. 2019; 16 (2): 75–82 DOI: 10.1292/2078-5658-2019-16-2-75-82 (in Russian).

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