Affiliation:
1. National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov of Ministry of Health of Russian Federation
Abstract
Acute and chronic neonatal pulmonary hypertension accompany all critical syndromes in newborns, both congenital and acquired. Use of all selective vasodilators for newborns and premature infants is off-label in the Russian Federation.The aim of the paper is to structure data on the pathogenesis of acute and chronic neonatal pulmonary hypertension in newborns and premature infants; to determine the pathogenetic and clinical aspects of the use of inhaled nitric oxide in neonatology; and to describe the experience of using a fundamentally new technology for generating nitrogen oxide from air with the Tianox apparatus.Conclusion. Inhaled nitric oxide is a proven, high-quality rescue technology for acute and chronic neonatal pulmonary hypertension in newborns and preterm infants. Inhalantion of nitric oxide with the use of a nitric oxide generator is an affordable and the most thoroughly developed technique in this population.
Publisher
Scientific and Practical Reviewed Journal Pulmonology
Reference80 articles.
1. Abdulatipova I.V., Belkina M.V., Belozerov Yu.M. et al. [Pulmonary hypertension in children: a guide]. Moscow: Actelion Pharmaceuticals; 2013 (in Russian).
2. Ministry of Health of the Russian Federation [Clinical guidelines. Mild hypertension in children]. Moscow; 2017. Available at: https://cr.minzdrav.gov.ru/recomend/31_1?ysclid=lwumvccw7r222227221 (in Russian).
3. Ruoss J.L., Rios D.R., Levy P.T. Updates on management for acute and chronic phenotypes of neonatal pulmonary hypertension. Clin. Perinatol. 2020; 47 (3): 593–615. DOI: 10.1016/j.clp.2020.05.006.
4. Burov A.A., Prutkin M.E., Grebennikov V.A. et al. [Draft clinical protocol for the diagnosis and treatment of persistent pulmonary hypertension in newborns]. Neonatologiya: novosti, mneniya, obuchenie. 2014; (1): 145–160 Available at: https://www.neonatology-nmo.ru/ru/jarticles_neonat/82.html (in Russian).
5. Miklashevich I.M., Shkolnikova М.A., Gorbachevsky S.V. et al. [Contemporary strategy of pulmonary hypertension management in pediatrics]. Kardiovaskulyarnaya terapiya i profilaktika. 2018; 17 (2): 101–124. DOI: 10.15829/1728-8800-2018-2-101-124 (in Russian).