Lung transplantation in a patient with α<sub>1</sub>-antitrypsin deficiency emphysema-Reference-Cited by-同舟云学术

Lung transplantation in a patient with α<sub>1</sub>-antitrypsin deficiency emphysema

Published:2022-12-11 Issue:6 Volume:32 Page:899-905
ISSN:2541-9617
Container-title:PULMONOLOGIYA
language:
Short-container-title:Pulʹmonologiâ (Mosk.)

Author:

Karchevskaya N. A.¹^ORCID,Kevorkova M. S.²^ORCID,Tarabrin E. А.³^ORCID,Kallagov T. Е.³^ORCID,Ibavov I. U.⁴^ORCID,Pervakova E. I.⁴^ORCID,Cherniaev A. L.⁵^ORCID,Samsonova M. V.⁶^ORCID,Khubutiya M. Sh.⁷^ORCID,Chuchalin A. G.²^ORCID

Affiliation:

1. N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department; Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia

2. Pirogov Russian National Research Medical University (Pirogov Medical University), Healthcare Ministry of Russia

3. N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

4. N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department

5. Pirogov Russian National Research Medical University (Pirogov Medical University), Healthcare Ministry of Russia; Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; A.P. Avtsyn Research Institute of Human Morphology

6. Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; A.S. Loginov Moscow State Clinical and Research Center, Moscow Healthcare Department

7. N.V. Sklifosovskiy State Research Institute of Emergency Care, Moscow Healthcare Department; A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation

Abstract

The condition of patients with chronic lung diseases is gradually deteriorating despite modern drug therapy and often progresses to severe respiratory failure. Thus, it is important to consider other options, including surgical methods, to help such patients. The aim of the study is to demonstrate potential additional pharmacological and surgical treatment algorithms for chronic obstructive pulmonary disease (COPD) associated with α1-anti-trypsin (A1AT) deficiency. Results. The analysis of long-term medical history (from the onset to the terminal stage of the respiratory failure) of a patient with A1AT deficiency was performed. Conclusion. Patients with COPD associated with A1AT deficiency require combination inhaled controller therapy and augmentation therapy with a1-proteinase inhibitor. Patients with terminal stage of the disease need lung transplantation unless they have any contraindications.

Publisher

Scientific and Practical Reviewed Journal Pulmonology

Subject

Pulmonary and Respiratory Medicine

Reference12 articles.

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