Affiliation:
1. State Budgetary Institution of Higher Professional Education “Voronezh State Medical University named after N.N.Burdenko”, Ministry of Public Health of the Russian Federation
2. Federal State Autonomous Educational Institution of Higher Education I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Abstract
One of the most important areas of modern medicine is the search for molecular biomarkers that open up new possibilities in fundamental research of pathological processes, allowing to diagnose human diseases with high accuracy and to implement a personalized approach to prescribe effective therapy. Currently, one of the promising molecular biomarkers in respiratory medicine is club cell protein (CC16, or secretory globulin SCGB1A1). Club-shaped cells are known to be involved in pulmonary homeostasis and regulate the progression of acute and chronic inflammatory processes in the bronchopulmonary system. Immunomodulation and regulation of inflammation by club-shaped cells is mediated by secretion of CC16 protein, which has pronounced anti-inflammatory, anti-allergic, and anti-tumor properties.The aim of the review is to collect and analyze data from recent domestic and foreign studies on the role of club-shaped cells and their CC16 protein in physiological and pathological processes in the airways.Conclusion. Based on the data of domestic and foreign studies presented in the review, it can be concluded that club-shaped cells and their secretory globulin SCGB1A1 play an important role in the physiological and pathological processes in the respiratory tract. Thus, club cell protein may serve as a molecular biomarker for diagnosing and monitoring the progression of certain bronchopulmonary diseases, for individual assessment of the treatment efficacy, and as a basis for the development of new therapies in respiratory medicine.
Publisher
Scientific and Practical Reviewed Journal Pulmonology
Subject
Pulmonary and Respiratory Medicine
Reference34 articles.
1. Chuchalin A. G. [Biological markers of respiratory diseases]. Terapevticheskiy arkhiv. 2014; 86 (3): 4–13. Available at: https://ter-arkhiv.ru/0040-3660/article/view/31429 (in Russian).
2. Don E.S., Tarasov A.V., Epshteyn O.I., Tarasov S.A. [The biomarkers in medicine: Search, choice, study and validation]. Klinicheskaya laboratornaya diagnostika. 2017; 62 (1): 52–59. Available at: https://cyberleninka.ru/article/n/biomarkery-v-meditsine-poisk-vybor-izuchenie-i-validatsiya?ysclid=l834ij5i3d329990941 (in Russian).
3. Budnevskiy A.V., Ovsyannikov E.S., Chernov A.V., Drobysheva E.S. [Diagnostic value of biomarkers of systemic inflammation in chronic obstructive pulmonary disease]. Klinicheskaya meditsina. 2014; 92 (9): 16–21. Available at: https://cyberleninka.ru/article/n/diagnosticheskoe-znachenie-biomarkerov-sistemnogo-vospaleniya-pri-hronicheskoy-obstruktivnoy-bolezni-legkih (in Russian).
4. Dobler C.C. Biomarkers in respiratory diseases. Breathe (Sheff.). 2019; 15 (4): 265–266. DOI: 10.1183/20734735.0329-2019.
5. Kewal K. Jain. Biomarkers of pulmonary diseases. In: The Handbook of Biomarkers. Humana Press; 2017: 673–688. DOI: 10.1007/978-1-4939-7431-3.