Lipopolysaccharide-binding protein and presepsin in patients with SARS-CoV-2 viral lung disease in the Republic of Crimea

Author:

Yatskov I. A.1ORCID,Beloglazov V. A.1ORCID,Kubyshkin A. V.1ORCID,Nikolaeva A. P.1ORCID,Zyablitskaya E. Yu.1ORCID,Kunitskaya Ju. E.1,Lavrenchu E. N.2ORCID

Affiliation:

1. S.I.Georgievsky Medical Academy, V.I.Vernadsky Crimean Federal University, Ministry of Science and Higher Education of the Russian Federation

2. State Budgetary Healthcare Institution of the Crimea Republic “N.A.Semashko Republican Clinical Hospital”

Abstract

Although more than 2 years have passed since the beginning of the pandemic of the new coronavirus infection, treatment and prediction of the course of SARS-CoV-2 infection remain pressing global problems. In this regard, the search for additional links in the pathogenesis of SARS-CoV-2 is currently one of the most important tasks. The Aim. To assess the level of lipopolysaccharide-binding protein (LBP) and presepsin (sCD14-ST) in patients with SARS-CoV-2 viral lung disease in Crimea.Methods. We examined 121 patients with a positive PCR result for SARS-CoV-2 in the age group of 45 – 75 years who were hospitalized in the Department of Infectious Diseases, State Budgetary Healthcare Institution of the Republic of Crimea “N.A.Semashko Republican Clinical Hospital”. Patients were divided into 3 clinical groups according to the severity of SARS-CoV-2 infection: Group 1 – patients with moderate disease, Group 2 – patients with severe disease, and Group 3 – patients with fatal outcome. Peripheral blood levels of LBP, presepsin, ferritin, and C-reactive protein were determined upon admission to the infectious disease hospital.Results. A significant increase in all studied parameters was observed in the 1st, 2nd and 3rd clinical groups of patients with coronavirus infection. This finding corresponds to the state of lipopolysaccharide-binding systems and systemic infection in patients with SARS-CoV-2 viral lung disease. The highest levels of LBP, sCD14-ST, and ferritin were registered in the 3rd clinical group. We found a direct correlation between LBP and sCD14-ST levels in the 2nd group (r = 0.523, p < 0.05) and the 3rd group (r = 0.748, p < 0.05).Conclusion. Patients with SARS-CoV-2 lung disease were found to have an increased blood levels of LBP and presepsin upon admission. The highest values were observed in patients with fatal outcome. Severe SARSCoV-2 lung damage was associated with a direct correlation between levels of LBP and sCD14-ST. Presepsin, LBP, and ferritin are important prognostic markers for severe SARS-CoV-2 lung damage and risk of death in the early stages of hospital treatment.

Publisher

Scientific and Practical Reviewed Journal Pulmonology

Subject

Pulmonary and Respiratory Medicine

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