The use of aqueous ozone solution in the treatment of mine blast injury with extensive soft tissue defects: A case study

Abstract

Mine explosions frequently result in severe and complex injuries, presenting challenges in wound management and infection control. This study aimed to examine the efficacy, safety, and practical implications of ozonated water in wound care for mine explosion injuries. A 37-year-old male soldier presented with extensive lacerations of both legs sustained during a mine explosion. Following initial stabilisation, foreign bodies removal and debridement, the patient was hospitalised where he underwent surgical intervention, and negative pressure wound therapy to repair tissue damage. Microbial cultures obtained from wound samples revealed the presence of multi-drug resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus. Antibiotic susceptibility testing indicated limited treatment options due to resistance of the isolated strains. Given the severity of the injuries and microbial colonisation, ozonated water was introduced as part of the wound care regimen. Topical application of ozonated water was initiated on admission and repeated with each dressing change. Over the course of treatment, the patient demonstrated significant improvement in wound healing, reduction in microbial burden, and resolution of infection signs. The use of ozonated water facilitated expedited wound closure and minimised the need for systemic antibiotics. This case highlights the potential of ozonated water as an effective adjunct therapy in the management of mine explosion wounds, particularly in cases of multi-drug resistant microbial colonisation. The findings underscore the practical value of ozonated water in improving wound care outcomes and reducing reliance on systemic antibiotics in complex trauma cases