Author:
Kovalchuk Tetiana,Boyarchuk Oksana
Abstract
There are many reports about the role of vitamins B6, B9, B12, and D in the development of cardiovascular diseases. However, most of them relate mainly to the adult population and are limited relative to grades in children with syncope. Understanding the role of these vitamins in the pathogenesis of syncope will help expand the range of therapeutic and preventive care for children. The purpose of the study was to analyse current scientific achievements regarding the role of the folate cycle and vitamin D in the genesis of syncope in childhood. The PubMed Medline and Scopus databases were used and the following search terms were used: “syncope” and “vitamin B”; “syncope” and “homocysteine”; “syncope” and “vitamin D”. The paper summarises the role of vitamin B12 deficiency in delayed myelination and nerve conduction, increased serum norepinephrine levels, and possible pathogenetic mechanisms for the development of noncardiogenic syncope. Scientific facts of the effect of vitamins B1, B6, and B9 on the functioning of the cardiovascular and nervous systems in children are described. The prevalence of vitamin D deficiency in 60-73% of children with vasovagal syncope and its relationship with the symptoms of the disease was established. Probable pathogenetic mechanisms of vitamin D deficiency in the development of syncope, namely a decrease in peripheral vascular resistance, a violation of neuronal conduction of the baroreflective mechanism, and heart muscle dysfunction, are analysed. The findings will allow doctors and researchers to better approach the diagnosis, prevention, and treatment of syncope in childhood and can serve as a basis for developing new strategies to manage the condition and improve medical practices
Publisher
Scientific Journals Publishing House
Subject
Marketing,Strategy and Management,General Materials Science,Media Technology
Reference62 articles.
1. [1] Lyon P, Strippoli V, Fang B, Cimmino L. B Vitamins and one-carbon metabolism: Implications in human health and disease. Nutrients. 2020;12(9):2867. DOI: 10.3390/nu12092867
2. [2] Chen H, Liu S, Ge B, Zhou D, Li M, Li W, et al. Effects of folic acid and vitamin B12 supplementation on cognitive impairment and inflammation in patients with Alzheimer's disease: A randomized, single-blinded, placebo-controlled trial. J Prev Alzheimers Dis. 2021;8:249-56. DOI: 10.14283/jpad.2021.22
3. [3] Khosravi M, Sotoudeh G, Amini M, Raisi F, Mansoori A, Hosseinzadeh M. The relationship between dietary patterns and depression mediated by serum levels of folate and vitamin B12. BMC Psychiatry. 2020;20:63. DOI: 10.1186/ s12888-020-2455-2
4. [4] Li WX, Cheng F, Zhang AJ, Dai SX, Li GH, Lv WW, et al. Folate deficiency and gene polymorphisms of MTHFR, MTR and MTRR elevate the hyperhomocysteinemia risk. Clin Lab. 2017;63(3):523-33. DOI: 10.7754/Clin.Lab.2016.160917
5. [5] Kumar A, Palfrey HA, Pathak R, Kadowitz PJ, Gettys TW, Murthy SN. The metabolism and significance of homocysteine in nutrition and health. Nutr Metab (Lond). 2017 Dec 22;14:78. PMID: 29299040; PMCID: PMC5741875. DOI: 10.1186/ s12986-017-0233-z
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献