Protective Effect of 3-Benzoyl-7-Hydroxy Coumarin on Lipid Peroxidation and Minerals on Rat Liver Tissues Induced Oxidative Stress with Lead Acetate

Author:

ÇİTİL Cihan1

Affiliation:

1. KAFKAS ÜNİVERSİTESİ, ATATÜRK SAĞLIK HİZMETLERİ MESLEK YÜKSEKOKULU, SAĞLIK BAKIM HİZMETLERİ BÖLÜMÜ

Abstract

Lead is a toxic substance and damages human metabolism. Coumarin-derived substances have many effects such as antioxidant, anticancer, and antibacterial ones. In this study, the effects of 3-benzoyl-7-hydroxy coumarin on rat liver tissues under oxidative stress with lead acetate were investigated. In the study, rats were divided into 4 groups. Control group (K), Coumarin group (KUM), Lead acetate group (P) and Coumarin+Lead acetate group (KUMP) groups were formed. Malondialdehyde (MDA), lead (Pb), iron (Fe), zinc (Zn), manganese (Mn), and copper (Cu) levels were determined in the liver tissues of the rats. MDA level of P group increased compared to the other groups. A decrease was observed in the KUMP group compared to the P group MDA level. While the Pb and Fe levels of the P group increased compared to the K group, the Pb and Fe levels of the KUMP group decreased compared to the P group. As a result, it is concluded that the 3-benzoyl-7-hydroxy coumarin molecule protects the high lipid peroxidation, lead, and iron metabolism caused by lead acetate in the liver.

Publisher

Commagene Journal of Biology

Subject

General Medicine

Reference49 articles.

1. Abdel Moneim, A.E., Dkhil, M.A., & Al-Quraishy, S. (2011). The redox status in rats treated with flaxseed oil and lead-induced hepatotoxicity. Biological trace element research, 143(1), 457–467. https://doi.org/10.1007/s12011-010-8882-z

2. Aksu, D.S., Saglam, Y.S., Yildirim, S., & Aksu, T. (2017). Effect of pomegranate (Punica granatum L.) juice on kidney, liver, heart and testis histopathological changes, and the tissues lipid peroxidation and antioxidant status in lead acetate-treated rats. Cellular and molecular biology, 63(10), 33-42. https://doi.org/10.14715/cmb/2017.63.10.5

3. Alonso, M.L., Montaña, F.P., Miranda, M., Castillo, C., Hern´andez, J., & Benedito, J.L. (2004). Interactions between toxic (As, Cd, Hg and Pb) and nutritional essential (Ca, Co, Cr, Cu, Fe, Mn, Mo, Ni, Se, Zn) elements in the tissues of cattle from NW Spain. Biometals, 17(4), 389-97. https://doi.org/10.1023/B:BIOM.0000029434.89679.a2

4. Atmaca, M., Bilgin, H.M., Obay, B.D., Diken, H., Kelle, M., & Kale, E. (2011). The hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats. Journal of physiology and biochemistry, 67(4), 569–576. https://doi.org/10.1007/s13105-011-0103-5

5. Aykin-Burns, N., Laegeler, A., Kellogg, G., & Ercal, N. (2003). Oxidative effects of lead in young and adult Fisher 344 rats. Archives of environmental contamination and toxicology, 44(3), 417–420. https://doi.org/10.1007/s00244-002-2023-4

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