Evaluation of the effect of carbamazepine on the concentration of vitellogenin in Pseudoplatystoma magdaleniatum

Author:

Ortiz Sylvia María Cacua1,Aguirre Néstor J.2,Peñuela Gustavo A.3

Affiliation:

1. GDCON Group, Environmental School, Faculty of Engineering, University Research Headquarters (SIU), University of Antioquia, calle 70 No 52 — 21, 050010, Medellin, Colombia

2. GeoLimna Group, Environmental School, Faculty of Engineering, University of Antioquia, calle 67 No 53 — 108,050010, Medellin, Colombia

3. GDCON Group, Environmental School, Faculty of Engineering, University Research Headquarters (SIU), University of Antioquia, calle 70 No 52— 21, 050010, Medellin, Colombia

Abstract

Abstract Carbamazepine is a pharmaceutical used in patients with seizures and bipolar disorder, which has been found in wastewater and many water resources. This is due to the inadequate disposal of pharmaceutical waste and the lack of treatment of municipal wastewater, as is the case in Colombia. The two main hydrographic basins of Colombia are the Cauca and Magdalena rivers, which are inhabited by the endemic species Striped Catfish (Pseudoplatystoma magdaleniatum). This has become an endangered species for various reasons, including the high contamination level of these rivers. In 2019, mature adult P. magdaleniatum of both sexes were caught in the Cauca river in Colombia. This was in order to assess the concentration of vitellogenin, as a biomarker of endocrine disruption, resulting from exposure to different levels of concentration of the emerging contaminant carbamazepine for 4 months. These tests were carried out in a fish farm. A significant decrease in the vitellogenin concentration was verified in females at concentrations of 25 µg l-1 and 50 µg l-1, and in males at 50 µg l-1 of carbamazepine, with a significance level of p˂0.05. Carbamazepine could cause a negative feedback in gonadotropin secretion, acting as an estrogen mimicker that causes a decrease in the level of vitellogenin.

Publisher

Michigan State University Press

Subject

Management, Monitoring, Policy and Law,Ecology,Aquatic Science

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3