Oncogenic Forms of Isocitrate Dehydrogenase: Mechanisms of Carcinogenesis and Development of Resistance to Chemotherapeutics
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Published:2022-09-15
Issue:9
Volume:116
Page:536-542
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ISSN:1213-7103
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Container-title:Chemické listy
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language:
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Short-container-title:Chem. Listy
Abstract
Many types of tumors harbor a mutation in the gene for the metabolic enzyme isocitrate dehydrogenase resulting in the production of the oncometabolite ᴅ-2-hydroxy glutarate with a pleiotropic effect on the cell. The paper provides an overview of the latest knowledge of the mechanism of carcinogenesis, of specific drugs suppressing ᴅ-2-hydroxy glutarate production and of the causes of resistance complicating treatment based on specific inhibitors of oncogenic forms of isocitate dehydrogenase.
Publisher
Czech Chemical Society
Subject
General Chemistry