Morphological Changes of Erythrocytes in Neonates with Perinatal Hypoxia-Reference-Cited by-同舟云学术

Morphological Changes of Erythrocytes in Neonates with Perinatal Hypoxia

Published:2023-07-01 Issue:4 Volume:65 Page:384-394
ISSN:0041-3771
Container-title:Цитология
language:
Short-container-title:Citologiâ

Author:

Denisenko O. D.¹,Perepelitsa S. A.¹²,Sergunova V. A.²,Lyapunova S. S.²,Litvinova L. S.¹

Affiliation:

1. Immanuel Kant Baltic Federal University

2. Negovsky Research Institute of General Resuscitation Federal Scientific, Clinical Center for Resuscitation and Rehabilitology

Abstract

Despite active research on the functional properties of erythrocytes under pathological conditions, this problem is of great importance. One of the causes of fetal and neonatal distress is hypoxia. The consequences of the negative effects of oxygen deficiency on the embryo and fetus can manifest both in utero and after birth, leading to various diseases. The aim of this work is to investigate the effects of acidosis as a marker of perinatal hypoxia on the erythrocyte membrane of newborns in the early neonatal period. The use of an atomic force microscope made it possible to obtain images and cell profiles to assess the morphological and structural characteristics of erythrocytes during hypoxia in children in the early neonatal period. Perinatal hypoxia has been shown to alter erythrocyte morphology and damage membrane structure. The early neonatal period is characterized by changes in the morphological forms and instability of erythrocyte membranes.

Publisher

The Russian Academy of Sciences

Reference46 articles.

1. Белевич Е.И., Костин Д.Г., Слобожанина Е.И. 2015. Активность каспазы-3 в эритроцитах человека при окислительном стрессе. Известия Национальной академии наук Беларуси. Серия биол. наук. № 2. С. 34. (Bialevich E.I., Kostin D.G., Slobozhanina E.I. 2015. Caspase-3 activity in human erythrocytes under oxidative stress. Izvestiya Natsional’noy Akademii Nauk Belarusi. Seriya boil. Nauk. № 2. P. 34.)

2. Ващенко В.И., Вильянинов В.Н. 2019. Эриптоз (квазиапоптоз) эритроцитов человека и его роль в лекарственной терапии. Обзоры по клинической фармакологии и лекарственной терапии. Т. 17. № 3. С. 5. (Vaschenko V.I., Vil’yaninov V.N. 2019. Eryptosis (quasi-apoptosis) of the human red blood cells. Its role in medicinal therapy. Reviews on Clinical Pharmacology and Drug Therapy. V. 17. P. 5.) https://doi.org/10.17816/RCF1735-38

3. Володин Н.Н. 2019. Неонатология. Национальное руководство. М.: ГЭОТАР-Медиа. (Volodin N.N. 2019. Neonatology: National guidelines. Short edition. M.: GEOTAR-Media.)

4. Кононенко В.Л. 2009. Фликкер эритроцитов. 1. Теоретические модели и методы регистрации. Биологические мембраны. Т. 26. № 5. С. 352. (Kononenko V.L. 2009. Red blood cell flicker. 1. Theoretical models and methods of registration. Biol. membranes. V. 26. № 5. P. 352)

5. Льюис С.М., Бэйн Б., Бэйтс И. 2009. Практическая и лабораторная гематология. М.: ГЭОТАР-МЕД. (L’juis S.M., Bjejn B., Bjejts I. 2006. Practical gematology. Churchill Livingstone.)