Decyclization of substituted 3-(4-nitrobenzoyl)hydrasono3<i>H</i>-furan-2-ones under the action of primary alcohols and investigation of analgesic activity and acute toxicity of reaction products

Abstract

The decyclization of substituted 3-(4-nitrobenzoyl)hydrazono-3 H -furan-2-ones under the action of primary alcohols, which proceeds with the formation of the corresponding substituted 2-[2-(4-nitrobenzoyl)hydrazono]-4-oxobutanoates, has been studied. The analgesic activity and acute toxicity of the obtained compounds were studied, it was found that the obtained compounds exhibit a pronounced analgesic effect, and also have low toxicity. According to the drug toxicity classification, the obtained primary substituted 2-[2-(4-nitrobenzoyl)hydrazono]-4-oxobutanoates belong to class V of practically non-toxic drugs.