Affiliation:
1. Ufa Institute of Chemistry - Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences
Abstract
The data on the synthesis of fluoroalkyl and fluoroaryl substituted hexahydropyrimidine derivatives from the moment of their first mention are systematized. Predominantly one-pot multicomponent synthesis methods, including catalytic ones, are considered. The effect of the nature of the catalyst, starting reagents, and synthesis conditions on the yield and composition of the resulting products is discussed, and the biological activity of some derivatives is also shown.
Publisher
The Russian Academy of Sciences