Affiliation:
1. The Ural Federal University named after the first President of Russia B.N. Yeltsin
2. Postovsky Institute of Organic Synthesis, UB, RAS
Abstract
The solvent-free interaction of 1,2,4-triazine-5-carbonitriles with first synthesized 5-hydroxyethylsulfanyland 5-hydroxyethoxyethylsulfanyl-3-amino-1,2,4-triazoles at heating has been studied. It was shown that the presence of these substituents at the C5 position of 1,2,4-triazole changes the direction of the reaction, and 5-amino-1,2,4-triazines are formed as the main products, while the products of the ipso -substitution of the C5-cyano group containing the moiety of the substituted 1,2,4-triazole were isolated only as by-products. In the case of using 1,2,4-triazole with a fragment of monoethylene glycol at C5 position of triazine, the formation of a complex mixture of products occurred.
Publisher
The Russian Academy of Sciences
Reference27 articles.
1. Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents
2. 1,2,4-Triazoles as Important Antibacterial Agents
3. Чупахин О.Н., Русинов В.Л., Уломский Е.Н., Чарушин В.Н., Петров А.Ю., Киселев О.И. Пат. 2294936 (2007). РФ. C.A. 2007, 146, 316949.
4. Чупахин О.Н., Чарушин В.Н., Русинов В.Л., Уломский Е.Н., Котовская С.К., Киселев О.И., Деева Э.Г., Саватеев К.В., Борисов С.С. Пат. 2529487 (2014). РФ. C.A. 2014, 161, 505376.
5. Electrochemical and spectroscopic evidences of corrosion inhibition of bronze by a triazole derivative