Chromatographic Determination of Drotaverine and Mathematical Modeling of Its Biodegradation in Soil-Reference-Cited by-同舟云学术

Chromatographic Determination of Drotaverine and Mathematical Modeling of Its Biodegradation in Soil

Published:2023-12-01 Issue:12 Volume:78 Page:1119-1127
ISSN:0044-4502
Container-title:Журнал аналитической химии
language:
Short-container-title:Žurnal analitičeskoj himii

Author:

Vikhareva E. V.¹²,Selyaninov A. A.³,Tyumina E. A.¹

Affiliation:

1. Perm Federal Research Center, Ural Branch, Russian Academy of Sciences, 614990, Perm, Russia

2. Perm State Pharmaceutical Academy, 614900, Perm, Russia

3. Perm National Research Polytechnic University, 614990, Perm, Russia

Abstract

The regularities of the biodegradation of drotaverine hydrochloride in soil by actinobacteria of the genus Rhodococcus in the presence of native microflora were studied. A method based on liquid–liquid extraction with chloroform followed by analysis using reverse-phase HPLC was proposed for determining the pharmaceutical pollutant in soil. A decrease in the ecotoxicant concentration by a factor of 100 in the course of its biodegradation was forecasted with a given probability of 95%.

Publisher

The Russian Academy of Sciences

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