On the Interaction of Gold(III) Complexes with Human Serum Albumin

Abstract

The interaction of gold(III) complexes (Au(bipy), Au(phen), and Au(dien-H)Cl+) with human serum albumin (HSA) was studied in aqueous solutions (pH 7.4, CNaCl = 0.2 M, CAu = (2–10) × 10–5 M, CHSA 6 × 10–4 M) at 25°C. In all cases, gold(III) is reduced to gold(I), which forms a complex with HSA. When an excess of HSA is present, the time required for complete transformation of the complexes does not exceed 1 h. In addition, it was shown that the redox reaction of gold(III) complexes with cysteine is much faster than the reaction with methionine.