Application of Metal-Organic Frameworks to High-Performance Liquid Chromatography

Abstract

We present a critical review of experimental studies of the efficiency of the separation of various groups of chemical compounds under the conditions of high-performance liquid chromatography using metal-organic framework polymers (metal-organic frameworks (MOFs)) or composite materials with MOFs as a stationary phase. MOFs demonstrated many advantages in high-performance liquid chromatography and a possibility of competing successfully with conventional phases, especially in the determination of low-molecular-weight compounds and optical isomers. Among the promising options for using this class of materials are the development of monolithic separation columns and hybrid adsorbents that eliminate the disadvantages of adsorbents based on pure MOFs.