Synthesis of Diethyl 6-Amino-1-aryl-2-oxo-1,2-dihydropyridine-3,5-carboxylate-Reference-Cited by-同舟云学术

Synthesis of Diethyl 6-Amino-1-aryl-2-oxo-1,2-dihydropyridine-3,5-carboxylate

Published:2024-09-03 Issue:4 Volume:94 Page:462-468
ISSN:0044-460X
Container-title:Журнал общей химии
language:
Short-container-title:Žurnal obŝej himii

Author:

Khachatryan A. Kh.¹²^ORCID,Avagyan K. A.¹^ORCID,Badasyan A. E.¹^ORCID

Affiliation:

1. Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

2. Crisis Management State Academy of the Ministry of Internal Affairs

Abstract

It was found that the reaction of malonic acid N-arylamidoesters with ethyl 2-cyano-3-ethoxyacrylate in ethanol in the presence of equimolar amounts of triethylamine both at room temperature and under reflux leads to the formation of previously unknown diethyl 6-amino-1-aryl-2-oxo-1,2-dihydropyridine-3,5-carboxylates with yields of 40–70%. Structure of the obtained compounds was confirmed by NMR and IR spectroscopy data. Antibacterial activity of some of the obtained compounds was studied.

Publisher

The Russian Academy of Sciences

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