Affiliation:
1. Kazan National Research University of Technology
Abstract
The complexation of cefotaxime with an anionic polysaccharide, sodium alginate, in aqueous solutions with different pH values was studied by conductometry and by UV and IR spectroscopy. The compositions and stability constants of the complexes were determined. At pH 2.0, 5.6, and 7.2, the composition of the complex of cefotaxime with alginate corresponds to the [cefotaxime] : [alginate] molar ratio of 4.0 : 1.0, 2.3 : 1.0, and 1.0 : 1.0, respectively. The cefotaxime–alginate complex is most stable in strongly acidic media.
Publisher
The Russian Academy of Sciences
Reference17 articles.
1. Яковлев В. П., Яковлев С. В. Рациональная антимикробная фармакотерапия. М.: ЛитТерра, 2007. 784 с.
2. Ling S. S. N., Magosso E., Khan N. A. C., Yuen K. H., Barker S. A. Enhanced oral bioavailability and intestinal lymphatic transport of a hydrophilic drug using liposomes // Drug. Dev. Ind. Pharm. 2006. V. 32. N 3. P. 335-345. https://doi.org/10.1080/03639040500519102
3. Pat. 11938638 USA (publ. 2007). Oral dosage form of ceftriaxone and methods of use.
4. Golocorbin-Kon S., Mikov M., Arafat M., Lepojevic Z., Mikov I., Sahman-Zaimovic M., Tomic Z. Cefotaxime pharmacokinetics after oral application in the form of 3α,7α-dihydroxy-12-keto-5β-cholanate microvesicles in rat // Eur. J. Drug Metabol. Pharmacokinet. 2009. V. 34. P. 31-36. https://doi.org/10.1007/BF03191381
5. Pat. 6248360B1 USA (publ. 2000).Complexes to improve oral absorption of poorly absorbable antibiotics.
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