Affiliation:
1. Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Abstract
A new method was developed for the synthesis of 5-arylidene-2,3-disubstituted 4 H -imidazol-4-ones by cyclization of N -substituted α,β-dehydroamino acid arylamides with N -trimethylsilylimidazole (TMSIM) in dimethylformamide. The process was carried out by both conventional and microwave heating. Target imidazol-4-one was also synthesized by a one-pot method based on the reaction of unsaturated 5(4 H )-oxazolone, arylamine, and TMSIM. The anticholinesterase and antiradical properties of synthesized both arylamides and 4-imidazolones were studied.
Publisher
The Russian Academy of Sciences