Kinetic stability and glass-forming ability of phenacetin by fast scanning calorimetry

Abstract

In the present work, an amorphous active pharmaceutical ingredient, phenacetin, was obtained by fast scanning calorimetry. The critical cooling rate and kinetic fragility of its supercooled melt were determined. The process of cold crystallization of phenacetin was studied by methods of isothermal and non-isothermal kinetics. It was found that the best correspondence between the two kinetic approaches is observed in the case of using the Nakamura crystallization model. The results obtained can find their application in the development of approaches to obtaining amorphous forms of drugs prone to crystallization.