Reaction of <i>o</i>-formylbenzoic acid with hydrazides of (iso)niconitic and hydroxybenzoic acids-Reference-Cited by-同舟云学术

Reaction of <i>o</i>-formylbenzoic acid with hydrazides of (iso)niconitic and hydroxybenzoic acids

Published:2023-09-15 Issue:9 Volume:93 Page:1326-1334
ISSN:0044-460X
Container-title:Журнал общей химии
language:
Short-container-title:Žurnal obŝej himii

Author:

Nurkenov O. A.¹²,Fazylov S. D.¹,Kulakov I. V.³,Seilkhanov T. M.⁴,Mendibayeva A. Zh.¹²,Syzdykov A. K.¹²,Kabieva S. K.²

Affiliation:

1. Institute of Organic Synthesis and Carbon Chemistry of the Republic of Kazakhstan

2. Karaganda Industrial University

3. Institute of Chemistry of Tyumen State University

4. Sh. Ualikhanov Kokshetau University

Abstract

The reaction of nicotinic and isonicotinic acid hydrazides with o -formyl benzoic acid in ethanol led to the formation of the corresponding hydrazones. It was found that o -formyl benzoic acid reacted in aldehyde form with hydrazides to form hydrazones. When heated in acetic anhydride, the latter are smoothly cyclized into 3-acetoxyisoindoline-1-ones. Structure of the synthesized compounds was proved by 1H and 13C NMR spectroscopy data. Antiradical and antiviral activity of the synthesized hydrazones and 3-acetoxyisoindoline-1-ones was studied. A compound with a wide spectrum of virus-inhibiting action against strains of the A virus was identified.

Publisher

The Russian Academy of Sciences

Reference44 articles.

1. Mini-Review of the Importance of Hydrazides and Their Derivatives—Synthesis and Biological Activity

2. A review exploring biological activities of hydrazones

3. Кулаков И.В., Нуркенов О.А., Газалиева М.А., Жаугашева С.К., Исакова Ж.О. // Хим.-фарм. ж. 2007. № 11. С. 52

4. Synthesis and tuberculostatic activity of N-aminoacetic acid hydrazides and acylhydrazides based on ephedrine alkaloids

5. Федоряк С.Д., Присяжнюк П.В., Сидорчук И.И. // Хим.-фарм. ж. 1982. № 1. С. 48