HIGH-CAPACITY CALCIUM CARBONATE PARTICLES AS PH-SENSITIVE CONTAINERS FOR DOXORUBICIN-Reference-Cited by-同舟云学术

HIGH-CAPACITY CALCIUM CARBONATE PARTICLES AS PH-SENSITIVE CONTAINERS FOR DOXORUBICIN

Published:2023-03-01 Issue:2 Volume:68 Page:298-305
ISSN:0023-4761
Container-title:Кристаллография
language:
Short-container-title:Kristallografiâ

Author:

Pallaeva T. N.¹,Mikheev A. V.¹,Khmelenin D. N.¹,Eurov D. A.²,Kurdyukov D. A.²,Popova V. K.³,Dmitrienko E. V.³,Trushina D. B.¹⁴

Affiliation:

1. Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, Moscow, 119333 Russia

2. Ioffe Institute, Russian Academy of Sciences, St. Petersburg, 194021 Russia

3. Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

4. I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

Abstract

Nanostructured submicron calcium carbonate particles with sizes of 500 ± 90 and 172 ± 75 nm have been synthesized by mass crystallization in aqueous solutions with addition of glycerol, as well as a mixture of polyethylene glycol, polysorbate, and a cellular medium. CaCO3 : Si : Fe nanoparticles 65 ± 15 nm in size have been obtained by template synthesis in pores of silica particles. The crystal structure and polymorphism of these particles are studied, and the influence of the size and structure of particles on the efficiency of their loading with a chemotherapy agent , as well as its release under model conditions at different рН, is determined.

Publisher

The Russian Academy of Sciences

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