AMINO DERIVATIVES OF ACRIDINE: SYNTHESIS, STUDY OF ANTICHOLINESTERASE AND ANTIOXIDANT ACTIVITIES-Reference-Cited by-同舟云学术

AMINO DERIVATIVES OF ACRIDINE: SYNTHESIS, STUDY OF ANTICHOLINESTERASE AND ANTIOXIDANT ACTIVITIES

Published:2023-03-01 Issue:1 Volume:509 Page:34-40
ISSN:2686-9535
Container-title:Доклады Российской академии наук. Химия, науки о материалах
language:
Short-container-title:Doklady Rossijskoj akademii nauk. Himiâ, nauki o materialah.

Author:

Shchepochkin A. V.¹²,Uglova A. F.¹²,Utepova I. A.¹²,Gradoblyanskaya E. S.²,Averkov M. A.¹²,Kovaleva N. V.³,Rudakova E. V.³,Boltneva N. P.³,Serebryakova O. G.³,Makhaeva G. F.³,Charushin V. N.¹²,Chupakhin O. N.¹²

Affiliation:

1. Institute of Organic Synthesis named by I.Y. Postovsky, Ural branch of the Russian Academy of Sciences

2. Ural Federal University named by the first President of Russia B.N. Yeltsin

3. Institute of Physiologically Active Substances of the Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry of the Russian Academy of Sciences

Abstract

A simple and accessible approach to the synthesis of new amine derivatives of acridine based on the direct C–H functionalization methodology was developed. The inhibitory effect of the synthesized compounds on cholinesterases and carboxylesterases, as well as their antioxidant activity, was studied. A moderate inhibition of BChE by the morpholine and pyrazole derivatives of acridine and a high anti-BChE activity of the N-methyl-piperazine one were shown.

Publisher

The Russian Academy of Sciences

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