Nanodiamonds as lutetium-177 carriers for nuclear medicine-Reference-Cited by-同舟云学术

Nanodiamonds as lutetium-177 carriers for nuclear medicine

Published:2024-09-13 Issue:2 Volume:66 Page:
ISSN:0033-8311
Container-title:Радиохимия
language:
Short-container-title:Radiohimiâ

Author:

Kazakov A. G.¹,Babenya J. S.¹,Ekatova T. Y.¹,Vinokurov S. E.¹,Khvorostinin E. Y.¹,Ushakov I. A.²,Zukau V. V.²,Stasyuk E. S.²,Nesterov E. A.²,Sadkin V. L.²,Rogov A. S.²,Myasoedov B. F.¹³

Affiliation:

1. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences

2. National Research Tomsk Polytechnic University

3. Interdepartmental Center for Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences

Abstract

The work investigated the sorption of carrier-free 177Lu isolated from neutron-irradiated 176Yb2O3, and with a carrier obtained by irradiation of natLu2O3, by commercial and oxidized nanodiamonds (NDs) of various brands from aqueous solutions to identify among them a promising carrier for further research for the purposes of nuclear medicine. A promising sorbent was found: oxidized NDs of the STP brand (ox-STP); conditions for the rapid sorption of lutetium by it in an amount equivalent to 1.2 GBq of carrier-free 177Lu were determined, which corresponds to the activity used in therapy.

Publisher

The Russian Academy of Sciences

Reference26 articles.

1. Phua V.J.X., Yang C.-T., Xia B., Yan S.X., Liu J., Aw S.E. et al. // Nanomaterials. 2022. Vol. 12. N 4. Article 582.

2. Islam W., Niidome T., Sawa T. // JPM. 2022. Vol. 12. N 12. Article 1964.

3. Abd Elkodous M., El-Sayyad G.S., Abdelrahman I.Y., El-Bastawisy H.S., Mohamed A.E., Mosallam F.M. et al. // Colloids Surf. B: Biointerfaces. 2019. Vol. 180. P. 411–428.

4. Lisik K., Krokosz A. // Int. J. Mol. Sci. 2021. Vol. 22. N 15. Article 8341.

5. Bayda S., Hadla M., Palazzolo S., Kumar V., Caligiuri I., Ambrosi E. et al. // J. Controlled Release. 2017. Vol. 248. P. 144–152.