Effect of strontium and calcium admixtures on productivity of 82Sr/82Rb medical generator-Reference-Cited by-同舟云学术

Effect of strontium and calcium admixtures on productivity of 82Sr/82Rb medical generator

Published:2023-12-15 Issue:5 Volume:65 Page:447-457
ISSN:0033-8311
Container-title:Радиохимия
language:
Short-container-title:Radiohimiâ

Author:

Chudakov V. M¹,Shatik S. V²,Zhuikov B. L¹

Affiliation:

1. Institute for Nuclear Research of Russian Academy of Sciences

2. Russian Scientific Center for Radiology and Surgical Technology

Abstract

The 82Sr/82Rb generator is used to produce a medical radiopharmaceutical rubidium-82 chloride in saline solution for PET investigation. In this work, we studied the effect of the amount of stable strontium and calcium delivered to the sorbent (hydrated tin dioxide), on the maximum volume of radiopharmaceutical solution that can be obtained from the generator. Sr and Ca may be delivered to the sorbent from the initial solution of strontium-82 or from the eluent (0.9% NaCl) during medical application of the generator. It is shown that this volume depends on the value CSr + 0.11CCa, where CSr and CCa - molar concentrations of the elements in 1 g of the sorbent. The obtained results make it possible to increase significantly the productivity and reliability of the used generators.

Publisher

The Russian Academy of Sciences

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