Changes in the visual areas of the cerebral cortex in children with left-sided anisometropic amblyopia according to structural MRI and resting-state fMRI

Author:

Gorev V. V.1,Gorbunov A. V.1,Panikratova Ya. R.2,Tomyshev A. S.2,Hatsenko I. E.1,Kuleshov N. N.1,Salmasi J. M.3,Hasanova K. A.1,Balashova L. M.4,Lobanova E. I.3,Lebedeva I. S.2

Affiliation:

1. Morozov Children Clinical Hospital

2. Mental Health Research Center

3. Pirogov Russian National Research Medical University

4. Noncommercial partnership «International scientific and practical center for tissue proliferation»

Abstract

Thanks to the development of structural and functional magnetic resonance imaging (MRI) methods, in recent decades there has been a lot of research aimed at elucidating brain abnormalities caused by amblyopia. In the cases of this prevalent visual disorder, the anomalies causing decreased visual acuity and other visual disabilities cannot be determined by standard ophthalmologic examination. Since there are several types of this disorder that are fundamentally different in etiology, it is natural to suggest the presence of different types of corresponding brain abnormalities. In this regard, before obtaining a general picture of the pathogenesis of amblyopia, studies conducted on groups of specially selected similar patients are very important. This paper presents the results of a study of school-age children with left-sided anisometropic amblyopia. In the patients investigated, MRI data revealed interhemispheric differences in the thickness of the lateral occipital cortex, and resting-state fMRI revealed interhemispheric differences in the local coherence of the hemodynamic signal within 17 Brodmann area and in the functional connectivity between 17 and 18+19 Brodmann areas. The data obtained contribute to the creation of a general MRI database on the pathophysiology of amblyopia, help clarify some controversial issues and indicate the advisability of using resting-state fMRI in ophthalmology.

Publisher

The Russian Academy of Sciences

Reference44 articles.

1. Alekseenko S. V., Shkorbatova P. Yu. Deprivacionnaya I disbinokulyarnaya ambliopiya: narusheniya v genikulo-korkovyh zritel’nyh putyah [Deprivation and dysbinocular amblyopia: disorders in the geniculo-cortical visual pathways]. Al’manah klinicheskoj mediciny [Almanac of Clinical Medicine], 2015. № 36. P. 97—100 (in Russian).

2. Alekseenko S. V., Shkorbatova P. Yu. Dinamika razvitiya anomalij v podkorkovom zritel’nom centre golovnogo mozga pri rannem narushenii binokulyarnogo opyta [The time course of abnormalities in the brain subcortical visual centre following early impairment of binocular experience] Al’manah klinicheskoj mediciny [Almanac of Clinical Medicine]. 2016. V. 44. № 3. P. 351—357 (in Russian).

3. Kononova N. E., Somov E. E. Ambliopiya I svyazannye s nej problem. [Amblyopia and related problems] Pediatrician. 2018. V. 9. № 1. P. 29—36.

4. Lebedeva I. S., Hacenko I. E., Sturov N. V., Guseva M. R., Lobanova I. V., Vyhristyuk O. F., Kyun Yu.A., Tomyshev A. S. Strukturnye osobennosti golovnogo mozga rebenka pri odnostoronnej ambliopii: MRT-issledovanie [Structural features of the child’s brain with unilateral amblyopia: a MRI study]. Zhurnal nevrologii I psihiatrii im S. S. Korsakova [S. S. Korsakov Journal of Neurology and Psychiatry]. 2018. № 2. P. 69—74 (in Russian). https://doi.org/10.17116/jnevro20181185269

5. Matrosova Yu. V. Etiopatogenez, klinikai metody lecheniya ambliopii [Etiopathogenesis, clinical picture and methods of treatment of patients with amblyopia]. Bulletin of the Novosibirsk State University. Series: Biology. Vestnik NGU. Seriya: Biologiya, klinicheskaya medicina. 2012. V. 10. № 3. P. 193—202 (in Russian).

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3