Interleukin-11 in Pathology of the Nervous System-Reference-Cited by-同舟云学术

Interleukin-11 in Pathology of the Nervous System

Published:2023-01-01 Issue:1 Volume:57 Page:3-9
ISSN:0026-8984
Container-title:Молекулярная биология
language:
Short-container-title:Molekulârnaâ biologiâ

Author:

Airapetov M. I.¹²,Eresko S. O.²³,Ignatova P. D.²,Lebedev A. A.²,Bychkov E. R.²,Shabanov P. D.²⁴

Affiliation:

1. Department of Pharmacology, St. Petersburg State Pediatric Medical University

2. Department of Neuropharmacology, Institute of Experimental Medicine

3. Research and Training Center of Molecular and Cellular Technologies, St. Petersburg State Chemical Pharmaceutical University

4. Department of Pharmacology, Kirov Military Medical Academy

Abstract

The study of the role of cytokines in various pathological conditions of the body is one of the topical areas of modern biomedicine. Interleukin 11 (IL-11) was discovered in 1990 in fibrocyte-like bone marrow stromal cells, but there has been an increased interest in the cytokine in recent years. The cytokine plays a significant role in the central nervous system; local expression of this cytokine by nerve cells has been shown. Studies show the involvement of IL-11 in the mechanisms of development of a number of pathologies of the nervous system. The review summarizes information that shows the involvement of IL-11 in the mechanisms of development of brain pathologies. Probably, in the near future, this cytokine will be able to find clinical application in the correction of mechanisms that are involved in the formation of pathological conditions of the nervous system.

Publisher

The Russian Academy of Sciences

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