Dinityrosyl Iron Complexes with Thiol-Containg Ligands as a Funcionally Active “Working Form” of Nitric Oxide System in Living Organisms

Abstract

The experimental data are summarized which allow to suggest that dinitrosyl iron complexes (DNIC) with thiol-containing ligands can be considered as an endogenous “working form” of nitric oxide (NO) system in living organisms. The complexes can function as donors of both neutral NO molecules as well as nitrosonium cations (NO+) which exert respectively positive (regulatory) or negative (cytotoxic) effect on human and animal organisms. A special attention is paid to DNIC capacity to block (especially in combination with dithiocarbamate derivatives) coronavirus SARS-CoV-2 infection in Syrian hamsters.