<i>JMJD3</i> Exerts Oncorepressor Activity in Acute Promyelocytic Leukemia by Promoting PU.1 Expression-Reference-Cited by-同舟云学术

<i>JMJD3</i> Exerts Oncorepressor Activity in Acute Promyelocytic Leukemia by Promoting PU.1 Expression

Published:2023-07-01 Issue:4 Volume:57 Page:665-667
ISSN:0026-8984
Container-title:Молекулярная биология
language:
Short-container-title:Molekulârnaâ biologiâ

Author:

Wang M.-X.¹²,Yu S.-H.¹,Xiao M.³,Chen J.¹

Affiliation:

1. Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

2. Department of Medical Oncology, Xuzhou Central Hospital, Xuzhou Medical University

3. Shanghai Ji Ai Genetics and IVF Institute, the Obstetrics and Gynecology Hospital of Fudan University

Abstract

All-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL) has been the most famous differentiation induction therapy during which the expression of PU.1, a key transcription factor (TF) for myeloid lineage determination in normal hematopoiesis is restored. In our previous studies, we found a stress-inducible H3K27 demethylase, JMJD3, to directly upregulate PU.1 expression to promote myeloid commitment during normal myelopoiesis. In addition, JMJD3 acts as an oncorepressor and plays a critical regulatory role in the initiation and progression of malignant hematopoiesis. In this study, we further resolved the relationship between JMJD3 and PU.1 in APL therein JMJD3 exerts oncorepressor activity via promoting PU.1 expression.

Publisher

The Russian Academy of Sciences

Reference32 articles.

1. Geissmann F., Manz M.G., Jung S., Sieweke M.H., Merad M., Ley K. (2010) Development of monocytes, macrophages, and dendritic cells. Science. 327(5966), 656‒661.

2. Lieschke G.J., Oates A.C., Paw B.H., Thompson M.A., Hall N.E., Ward A.C., Ho R.K., Zon L.I., Layton J.E. (2002) Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning. Dev. Biol. 246(2), 274‒295.

3. Scott E.W., Simon M.C., Anastasi J., Singh H. (1994) Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 265(5178), 1573‒1577.

4. DeKoter R.P., Singh H. (2000) Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science. 288(5470), 1439‒1441.

5. Dahl R., Walsh J.C., Lancki D., Laslo P., Iyer S.R., Singh H., Simon M.C. (2003) Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPalpha ratio and granulocyte colony-stimulating factor. Nat. Immunol. 4(10), 1029‒1036.