Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair-Reference-Cited by-同舟云学术

Alternative Mechanisms of Mutagenesis at mCpG Sites during Replication and Repair

Published:2023-07-01 Issue:4 Volume:57 Page:587-596
ISSN:0026-8984
Container-title:Молекулярная биология
language:
Short-container-title:Molekulârnaâ biologiâ

Author:

Shilkin E. S.¹,Petrova D. V.²³,Zharkov D. O.²³,Makarova A. V.¹

Affiliation:

1. Institute of Molecular Genetics, National Research Center “Kurchatov Institute”

2. Institute of Сhemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences

3. Novosibirsk State University

Abstract

5-Methyl-2'-deoxycytidine (mC) at CpG sites plays a key role in the epigenetic gene function regulation, cell differentiation and carcinogenesis. Despite the importance of mC for normal cell function, CpG dinucleotides are known as mutagenesis hotspots. mC is deaminated with the formation of T, causing C→T transitions. However, several recent studies demonstrated the effect of epigenetic modifications of C on the fidelity and efficiency of DNA polymerases and excision repair enzymes. This review summarizes the known data indicating the existence of mutagenesis mechanisms independent of deamination at CpG sites.

Publisher

The Russian Academy of Sciences

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